IL6R-STAT3-ADAR1 (P150) interplay promotes oncogenicity in multiple myeloma with 1q21 amplification
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چکیده
منابع مشابه
1q21/1p21 in the Evaluation of Patients with Multiple Myeloma
The hallmark of Lynch Syndrome is a germ line mutation in one of the enzymes involved in DNA mismatch repair (MMR). The diagnosis of Lynch Syndrome is of particular relevance in colorectal and endometrial cancer cases, and several testing modalities including IHC, PCR, methylation studies, and genetic sequence analysis are used for its evaluation. As many sporadic cancers exhibit MMR deficiency...
متن کاملThe amplification of 1q21 is an adverse prognostic factor in patients with multiple myeloma in a Chinese population
The prognostic heterogeneity of multiple myeloma (MM) is largely due to different genetic abnormalities. Cytogenetic analysis has revealed that most of MM harbor chromosome aberrations. Amplification of 1q21 is one of the most common chromosomal aberrations. Interphase fluorescence in situ hybridization was applied to detect the 1q21 amplification in 86 Chinese patients with newly diagnosed MM....
متن کاملMULTIPLE MYELOMA Amplification and overexpression of CKS1B at chromosome band 1q21 is associated with reduced levels of p27 and an aggressive clinical course in multiple myeloma
The molecular basis for aggressive transformation of multiple myeloma (MM) and other cancers is not completely understood. Global gene expression profiling on highly purified malignant plasma cells from 351 newly diagnosed patients with MM treated with autologous stem cell transplantation revealed a statistically significant over-representation of chromosome 1 genes in a group of 70 genes whose...
متن کاملMultiple Myeloma Update
This literature review presents the most recent developments in the management of multiple myeloma, which is characterized by the presence of abnormal plasma cells (myeloma cells) that accumulate into the bone marrow. Aspects related to pathophysiology, clinical manifestations, laboratory, study and treatment are described. These pieces of information are necessary to accomplish a better ...
متن کاملPyk2 promotes tumor progression in multiple myeloma.
Proline-rich tyrosine kinase 2 (Pyk2) is a member of the focal adhesion kinase family that has been recently linked to tumor development. However, its role in modulating multiple myeloma (MM) biology and disease progression remains unexplored. We first demonstrated that patients with MM present with higher expression of Pyk2 compared with healthy individuals. By using loss-of-function approache...
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ژورنال
عنوان ژورنال: Haematologica
سال: 2019
ISSN: 0390-6078,1592-8721
DOI: 10.3324/haematol.2019.221176